NCT00795288

Statins and Cerebral Blood Flow in Subarachnoid Hemorrhage (SAH)

Effect of Statins on Cerebral Blood Flow After Subarachnoid Hemorrhage

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The primary objective of this project is to investigate the effect of statin therapy on cerebral blood flow in patients with aneurysmal SAH who are randomized to receive or not receive statins in a blinded design.

Detailed description

We will determine if statin therapy improves CBF in patients with aneurysmal subarachnoid hemorrhage. This improvement, if present, may be due to improved basal CBF, improved autoregulatory function, or a mitigation of large arterial narrowing. The information gain from this study will help us to better understand the mechanism of action of statins. This knowledge may be useful in the design of future studies with statins and in the development of other therapies aimed at similar mechanisms.

Conditions

• Subarachnoid Hemorrhage

Interventions

Type	Name	Description
DRUG	Simvastatin, 80 mg/day for 21 days	Active treatment group
DRUG	placebo	Control group

Timeline

• Start date: 2008-08-01
• Primary completion: 2013-02-01
• Completion: 2013-12-01
• First posted: 2008-11-21
• Last updated: 2016-03-21
• Results posted: 2015-01-16

Locations

1 site across 1 country: United States