NCT00790270

Comparison of Ibuprofen, Cyclobenzaprine, or Both for Acute Cervical Strain: A Randomized Clinical Trial

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 61 (actual)
• Sponsor: Stony Brook University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to see whether the combination of a muscle relaxant and anti-inflammatory drug is more effective at relieving pain in patients with neck strains or whiplash than either of the two medications alone.

Detailed description

Muscle relaxants have been used extensively for neck and back pain since muscle spasm is thought to play a role in the cycle of pain and spasm. However, prior studies have conflicting results regarding their additive effect when given in addition to analgesics such as the NSAIDs. Because they have the potential to lead to adverse events their efficacy should be clearly demonstrated before their routine use.

Conditions

• Cervical Strain

Interventions

Type	Name	Description
DRUG	Cyclobenzaprine	5 mg orally every 8 hours as needed
DRUG	Ibuprofen	Ibuprofen 400 mg every 8 hours as needed
DRUG	Ibuprofen plus Cyclobenzaprine	Ibuprofen 400 mg plus cyclobenzaprine 5 mg every 8 hours as needed

Timeline

• Start date: 2003-01-01
• Primary completion: 2004-01-01
• Completion: 2004-01-01
• First posted: 2008-11-13
• Last updated: 2012-11-21
• Results posted: 2012-11-21

Locations

1 site across 1 country: United States