NCT00789152

The Effect of Desloratadine and Levocetirizine on Nasal Obstruction (Study P03609)

The Effects of Desloratadine and Levocetirizine on Nasal Obstruction in Subjects With Induced Allergic Rhinitis in the VCC Assessed Clinically and With Nasal Rhinomanometry and Nasal Flowmetry

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 81 (actual)
• Sponsor: Organon and Co · Industry
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

This was a study to measure the ability of desloratadine and levocetirizine to decrease nasal obstruction in subjects who had study-induced allergic rhinitis. Study participants had allergic rhinitis symptoms induced in a Vienna Challenge Chamber and then received desloratadine or levocetirizine for 8 days. After at least a 10 to 35-day washout period (time when no drug is given), subjects received the opposite treatment for 8 days. Subjects had their total nasal symptom measured.on the 8th day of each treatment period.

Conditions

• Allergic Rhinitis

Interventions

Type	Name	Description
DRUG	desloratadine	desloratadine 5 mg daily x 8 days
DRUG	levocetirizine	levocetirizine 5 mg daily x 8 days

Timeline

• Start date: 2003-12-01
• Primary completion: 2004-05-01
• Completion: 2004-05-01
• First posted: 2008-11-11
• Last updated: 2024-08-15