NCT00784030

High Water Intake to Slow Progression of Polycystic Kidney Disease

The Effect of Water Loading on Urinary Biomarkers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: NYU Langone Health · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Polycystic kidney disease (PKD) is a genetic disease that occurs in 1 in 500 individuals and leads to kidney failure in half of all affected. Currently, no treatments exist for PKD. PKD-affected kidney cells divide and multiply inappropriately, and form fluid-filled sacs called cysts. Kidney cysts continue to grow throughout life, destroying normal kidney tissue, leading to kidney failure. Based on evidence from basic science research it is believed that drinking high amounts of water can slow the abnormal cysts growth. This study aims to look at changes in urine composition with high water intake in PKD-affected persons compared to healthy individuals.

Conditions

• Kidney, Polycystic, Autosomal Dominant

Interventions

Type	Name	Description
OTHER	Water	Participants will be first asked to drink 6 8-oz glasses of water over 2.5 hours on the first day, and then about 12 8-oz glasses of water over the course of the day for one week.

Timeline

• Start date: 2008-11-01
• Primary completion: 2009-05-01
• Completion: 2009-05-01
• First posted: 2008-11-03
• Last updated: 2016-04-06
• Results posted: 2016-04-06

Locations

1 site across 1 country: United States