Trials / Terminated
TerminatedNCT00780481
Characterization of Brachial Arterial t-PA Release, Endothelial Function, Obesity and Inflammation
Characterization of Brachial Arterial t-PA Release, Vasodilator Function, and Vascular Compliance and Correlation With Fibrinolytic Balance, Oxidative Stress, and Inflammation Measures (SCCOR Project 1 Aim 3B)
- Status
- Terminated
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 13 (actual)
- Sponsor
- Vanderbilt University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
T-PA release is impaired in obese subjects. In order to have a better mechanistic understanding of t-PA release, we will compare t-PA release to Flow Mediated Vasodilation, Radial Artery Tonometry, and other markers of endothelial function and oxidative stress.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Bradykinin | Intrabrachial - 0, 10, 20, 40 ng/100cc/min over 5 minutes at each dose. |
Timeline
- Start date
- 2007-01-01
- Primary completion
- 2011-01-01
- Completion
- 2011-05-01
- First posted
- 2008-10-27
- Last updated
- 2017-07-14
- Results posted
- 2017-07-14
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00780481. Inclusion in this directory is not an endorsement.