NCT00780377

Intracoronary Bradykinin Mediated t-PA Release in Heart Transplant Recipients

The Effects of Cardiac Innervation on Intra-coronary t-PA Release

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Heart transplant recipients do not have nerves to their hearts. This protocol tests the hypothesis that bradykinin mediated t-PA release in the coronary arteries will be reduced in heart transplant recipients compared to healthy subjects. This study will compare heart transplant recipients to healthy controls who are undergoing cardiac cath for standard of care purposes (separate protocol) and compare the coronary arteries to the forearm in transplant recipients (separate protocol) and healthy controls (separate protocol).

Conditions

• Heart Transplantation

Interventions

Type	Name	Description
DRUG	Bradykinin	Bradykinin 0, 0.2, 0.6, 2.0 ug/min intracoronary, for 5 minutes at each dose.

Timeline

• Start date: 2008-10-01
• Primary completion: 2011-01-01
• Completion: 2011-05-01
• First posted: 2008-10-27
• Last updated: 2017-03-20

Locations

1 site across 1 country: United States