NCT00778011

Uncomplicated Nausea and Vomiting in the Emergency Department

Ondansetron 4 mg vs. 2 mg vs. Metoclopramide 10 mg for Nausea and Vomiting in the Emergency Department: A Randomized, Double-Blind Clinical Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 137 (actual)
• Sponsor: WellSpan Health · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Nausea and vomiting is a common complaint in the emergency department. Treatment is important for many reasons. In addition to patient comfort, there are adverse effects secondary to vomiting such as dehydration, metabolic alkalosis, Mallory-Weiss tears, and aspiration. Two mediations common used for nausea in ED patients include Ondanesetron and Metoclopramide.

Detailed description

This study will compare Ondansetron 4 mg vs 2 mg vs Metoclopramide 10 mg to look for efficacy in nausea and vomiting treatment for patients in the ED with many different causes. We will also look for cost effectiveness as well, since Metoclopramide is much less expensive than Ondansetron, which is less expensive at lower doses. There is little research about nausea medication in the ED literature even though these medications are used frequently in the ED for many causes of nausea.

Conditions

• Nausea
• Vomiting

Interventions

Type	Name	Description
DRUG	Ondansetron	dosage
DRUG	Ondansetron	4 mg
DRUG	Metoclopramide	10 mg IV

Timeline

• Start date: 2005-11-01
• Primary completion: 2006-12-01
• Completion: 2006-12-01
• First posted: 2008-10-23
• Last updated: 2012-06-28

Locations

1 site across 1 country: United States