NCT00777712

Mechanisms Underlying Impaired Diabetic Wound Healing

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 250 (estimated)
• Sponsor: University of Pittsburgh · Academic / Other
• Sex: All
• Age: 21 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The overall aim of this research is to utilize wound derived inflammatory cells from diabetic versus non diabetic human chronic wounds to understand mechanisms that are responsible for disregulated inflammation in individuals with diabetes. Biology of normal (peripheral blood derived cells) versus wound derived cells will also be studied.

Detailed description

Specific aims: 1. To study biology of wound derived inflammatory cells and fluid from diabetic versus non diabetic wounds. 2. To characterize mechanisms that are responsible for dysregulated wound inflammatory cell function in individuals with diabetes. 3. To characterize differences in the biology of normal peripheral blood derived cells versus wound derived cells. The long-term goal of this study is to determine the molecular mechanisms underlying impaired wound healing in diabetics.

Conditions

• Non-healing Wounds
• Diabetes

Interventions

Type	Name	Description
OTHER	Blood draw	Blood will be drawn from subjects once and VAC sponge will be collected (which is normally discarded material per standard of care).

Timeline

• Start date: 2008-09-01
• Primary completion: 2029-12-31
• Completion: 2030-12-31
• First posted: 2008-10-22
• Last updated: 2025-06-03

Locations

5 sites across 1 country: United States