NCT00777621

Caloric Restriction, Exercise, and Glucoregulation in Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 69 (actual)
• Sponsor: St. Louis University · Academic / Other
• Sex: All
• Age: 45 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Weight loss induced by caloric restriction alone (CR) and by exercise alone (EX) result in similar effects on blood glucose and insulin. The purpose of this study is to assess the hypothesis that weight loss through caloric restriction plus exercise will result in greater improvements on glucose tolerance and insulin action than similar weight losses through CR or EX alone.

Detailed description

Participants are randomized into caloric restriction, exercise, and caloric restriction plus exercise weight loss groups. Measurements of blood glucose and insulin, oral glucose tolerance, and matched glucose infusion will be done at baseline and after weight loss of 6% of body weight. Other tests include maximal oxygen uptake (VO2max), strength tests, blood pressure, blood lipids, serum inflammatory markers, dual X-ray absorptiometry (DEXA) for bone density and body composition, physical activity levels, dietary intakes, and measures of arterial stiffness.

Conditions

• Diabetes

Interventions

Type	Name	Description
OTHER	Calorie Restriction	This group will undergo a 20% reduction in energy intake without any change in energy expenditure.
OTHER	Exercise	This group will undergo a 20% increase in energy expenditure by exercising without any change in energy intake.
OTHER	Calorie Restriction and Exercise	This group will undergo 10% reduction in energy intake and a 10% increase in energy expenditure via exercise.

Timeline

• Start date: 2008-04-01
• Primary completion: 2015-03-01
• Completion: 2015-03-01
• First posted: 2008-10-22
• Last updated: 2016-02-12

Locations

1 site across 1 country: United States