NCT00774098

Improving Glycogen Liver Content Will Improve Post-operative Liver Function in Patients Undergoing Major Liver Resections

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

We would like to study the effect of preserving liver glycogen storage by using intravenous dextrose infusion on postoperative liver function and complications after major liver resections.

Conditions

• Liver Function

Interventions

Type	Name	Description
DRUG	dextrose 10% (D10W ®) infusion	Started at 8pm the day before surgery until the procedure begins
DRUG	hyperinsulinemic normoglycemic clamp	Started as the procedure begins, decreased at the end of the procedure and continued until 16 hours postoperatively
DIETARY_SUPPLEMENT	high calorie diet 35 kcal/kg	High Calorie meals start the day before the surgery and are given 5 hours apart. The last meal is given at 7 pm the day before surgery
DRUG	Intravenous normal saline (NS 0.9)	Intravenous normal saline (NS 0.9) started just before induction, and titrated to hemodynamic parameters and urine output

Timeline

• Start date: 2007-01-01
• Primary completion: 2009-09-01
• Completion: 2009-09-01
• First posted: 2008-10-17
• Last updated: 2010-04-01

Locations

1 site across 1 country: Canada