NCT00772616

Influence of Intraoperative Analgesia on the Postoperative Morphine Consumption

Influence of Intraoperative Analgesia (Sufentanil Administered According to the Usual Criteria or Remifentanil Administered by a Closed-loop System Using Bispectral Index as the Controller) on the Postoperative Morphine Consumption

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Hopital Foch · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Unlike longer acting opiates (sufentanil), remifentanil may provoke postoperative hyperalgesia. We have developed two automated bispectral index - guided drug delivery systems: one for propofol administration, the other for combined propofol and remifentanil administration. Both systems achieve the same objective: similar level of anesthesia indicated by bispectral index levels between 40 to 60. We make the assumption that this method of automated remifentanil administration may avoid postoperative hyperalgesia. Patients scheduled for abdominal surgery will be divided into two groups: * in one group, patients will receive automatically delivered propofol and manually delivered sufentanil according to the usual criteria, * in the other group, patients will receive propofol and remifentanil both automatically administered. Assessment of postoperative hyperalgesia will be primarily based on morphine consumption (patient controlled analgesia) and detection of cutaneous hyperalgesia areas.

Conditions

• Anesthesia

Interventions

Type	Name	Description
DRUG	Remifentanil	closed-loop administration using bispectral index as the single input for the controller.
DRUG	Sufentanil	dosage according to usual criteria

Timeline

• Start date: 2008-09-01
• Primary completion: 2010-01-01
• Completion: 2011-01-01
• First posted: 2008-10-15
• Last updated: 2016-09-23

Locations

1 site across 1 country: France