NCT00769678

Stimulation of the Diaphragm in Patients With Severe Heart Failure Following Heart Surgery

Biventricular Pacing and Stimulation of the Diaphragm in Patients With Severe Heart Failure Following Heart Surgery (Epiphrenic II Pilot Trial)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: Luzerner Kantonsspital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study examines whether a permanent stimulation of the diaphragm improves left ventricular function in patients with severe heart failure following heart surgery.

Detailed description

Previous studies have shown that temporary stimulation of the diaphragm using an electrode to the phrenic nerve reduces electrical mechanical activation time (EMAT) and improves left ventricular function. This study examines whether patients with severe heart failure, who require permanent biventricular pacing after heart surgery, may benefit from an additional permanent electrode that stimulates the diaphragm. Heart function is assessed by echocardiography and acoustic cardiography (Audicor, Inovise Medical Inc., Portland, USA).

Conditions

• Heart Failure

Interventions

Type	Name	Description
DEVICE	Stimulation of the diaphragm	Stimulation of the diaphragm using an electrode

Timeline

• Start date: 2008-10-01
• Primary completion: 2012-05-01
• First posted: 2008-10-09
• Last updated: 2013-04-17

Locations

1 site across 1 country: Switzerland