NCT00769223

Predicting the Risk of Failure in Patients Undergoing Radiation Therapy for Localized Prostate Cancer

Pre-Operative Gleason Score and PSA and Clinical Stage in Predicting the Risk of Failure in Patients Undergoing Radiation Therapy for Localized Prostate Cancer

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 3,561 (actual)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: Male
• Age: 18 Years – 120 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Gathering information about the Gleason score, prostate-specific antigen (PSA) level, and cancer stage from patients who have undergone radiation therapy for prostate cancer may help doctors predict how patients respond to treatment and help plan the best treatment. PURPOSE: This clinical trial is studying the Gleason score, PSA level, and cancer stage in predicting outcome in patients who have undergone radiation therapy for localized prostate cancer.

Detailed description

OBJECTIVES: * Evaluate the value of the pre-operative Gleason score, prostate-specific antigen level, and clinical stage in predicting the risk of failure and death in patients who have undergone radiotherapy for localized prostate cancer. OUTLINE: This is a multicenter study. Patient medical records are reviewed to collect data about pre-treatment prostate biopsy, assigned Gleason score, prostate-specific antigen level, and radionucleotide bone scan. Patients complete a Bowel Toxicity questionnaire to assess quality of life related to acute and long-term bowel toxicity after radiotherapy.

Conditions

• Prostate Cancer
• Radiation Toxicity

Interventions

Type	Name	Description
OTHER	medical chart review
OTHER	questionnaire administration
PROCEDURE	quality-of-life assessment
RADIATION	brachytherapy
RADIATION	radiation therapy

Timeline

• Start date: 1993-02-25
• Primary completion: 2026-01-31
• Completion: 2026-01-31
• First posted: 2008-10-09
• Last updated: 2025-03-20

Locations

1 site across 1 country: United States