NCT00768157

Efficacy of Antiviral Therapy After Radical Resection for Hepatitis B Virus-Related Hepatocellular Carcinoma

Efficacy of Antiviral Therapy With Lamivudine or Entecavir After Radical Resection for Hepatitis B Virus-Related Hepatocellular Carcinoma

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Sun Yat-sen University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Most hepatocellular carcinomas are associated with hepatitis B virus, it is hypothesized that anti-viral treatment may be helpful in treating HBV-related hepatocellular carcinoma.

Detailed description

As we know, recurrence and metastasis could happen in hepatocellular carcinoma even after radical resection.One reason is that virus hepatitis B could be one factor contributing to the carcinogenesis of hepatocellular carcinoma.To investigated whether anti-viral therapy could improve the efficacy of radical resection of hepatitis B virus (HBV)-related hepatocellular carcinoma(HCC),we planed to conduct this clinical trial.

Conditions

• Hepatocellular Carcinoma
• Hepatitis B Virus
• Recurrence

Interventions

Type	Name	Description
DRUG	antiviral treatment (lamivudine or entecavir)	antiviral treatment (lamivudine 100mg per day or entecavir 0.5mg per day)
PROCEDURE	radical resection of HBV-related HCC	Procedure/Surgery - radical resection of HBV-related HCC

Timeline

• Start date: 2007-04-01
• Primary completion: 2009-08-01
• Completion: 2010-08-01
• First posted: 2008-10-07
• Last updated: 2009-02-09

Locations

1 site across 1 country: China