NCT00765453

Bone Marrow Derived Adult Stem Cells for Acute Anterior Myocardial Infarction

Randomised Controlled Clinical Trial of the Use of Autologous Bone Marrow Derived Progenitor Cells to Salvage Myocardium in Patients With Acute Anterior Myocardial Infarction

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Barts & The London NHS Trust · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Study hypothesis : The purpose of this study is to determine whether Intracoronary infusion of autologous bone marrow derived progenitor cells to patients undergoing primary angioplasty for acute anterior myocardial infarction will lead to an improvement in cardiac function greater than that seen by placebo alone. Aims * To demonstrate that it is safe and feasible to deliver autologous bone marrow derived stem cells within hours of the primary angioplasty procedure * To demonstrate the effects of autologous bone marrow derived stem cells on cardiac function using cardiac MRI (or cardiac CT), echocardiography and left ventriculography. * To demonstrate the effect of autologous bone marrow derived stem cells in addition to standard care leads to improvement in cardiac function compared to patients saline(placebo) and standard care.

Conditions

• Acute Myocardial Infarction

Interventions

Type	Name	Description
OTHER	Bone marrow derived progenitor cells or placebo infusion	Over-the-wire balloon catheter delivers infusion into coronary vessel using a stop-flow technique
OTHER	Placebo infusion	Placebo infusion

Timeline

• Start date: 2008-03-01
• Primary completion: 2014-03-01
• Completion: 2018-03-01
• First posted: 2008-10-03
• Last updated: 2020-03-02

Locations

5 sites across 3 countries: Denmark, Switzerland, United Kingdom