NCT00764413

Chronotherapy in Acute Multiple Sclerosis (MS) Attack

Treatment With Methylprednisolone in Acute Exacerbations of Multiple Sclerosis: Enhanced Effect With Nighttime Treatment?

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 57 (actual)
• Sponsor: Sykehuset Innlandet HF · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The Immunological system is showing a diurnal rhythmicity. The Mediators that enhances inflammation are at highest level during the night. At the same time the endogenous production of cortisol is at its lowest. We want to study if there is a better effect of treatment with Methylprednisolone for acute MS-attacks if given at nighttime. The effect will be measured in relation to neurological deficits and function with Kurtzkes Expanded Disability Status Score (EDSS) and Multiple Sclerosis Functional Composite (MSFC). We want to see if the mean improvement in EDSS is greater in the group receiving treatment at night opposed to the group that get treatment during the daytime.

Conditions

• Multiple Sclerosis

Interventions

Type	Name	Description
DRUG	methylprednisolone	1 gram intravenous a day for 3 days
DRUG	Sodium chlorid	Sodium chlorid 9mg/ml 500 ml per day in 3 days

Timeline

• Start date: 2009-04-01
• Primary completion: 2012-07-01
• Completion: 2012-07-01
• First posted: 2008-10-02
• Last updated: 2014-11-24

Locations

1 site across 1 country: Norway