NCT00763997

Study of the Effect of Dipyrone, Ibuprofen, Paracetamol and Parecoxib on the Platelet Aggregation in Analgetic Dosages

Study of the Effect of Dipyrone, Ibuprofen, Paracetamol and Parecoxib on the Platelet Aggregation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Ruhr University of Bochum · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Dipyrone is suggested to inhibit the platelet aggregation comparable to th effect of traditional analgetic substances like Ibuprofen. To verify this hypothesis the investigators conducted the study in comparing patients undergoing traumatologic, visceral or plastic surgical procedures. The investigators randomized them to four groups receiving common analgetic doses of either dipyrone, acetaminophen (paracetamol) or valdecoxib/parecoxib. The investigators took blood samples before initiation of the study drug, 1h, 4hs and 24hs after first intake. The investigators compared the aggregation via aggregometry of platelet rich plasma.

Conditions

• Platelet Aggregation

Interventions

Type	Name	Description
DRUG	dipyrone	Dipyrone is given in the operation room with 2,5 g intravenously, followed by an oral regime of 4x1g on the ward
DRUG	Ibuprofen	Ibuprofen is given orally 600mg in the Post Anesthesia Care Unit, followed by an oral regime of 800mg twice a day
DRUG	Acetaminophen	Acetaminophen is given 1g intravenously in the Operation room, followed by an oral regime of 1g fourth a day
DRUG	Acetaminophen	Acetaminophen is given 1g intravenously in the operation room, followed by 1g orally fourth a day
DRUG	Parecoxib/Valdecoxib	40mg Parecoxib are given intravenously in the operation room, followed by 40mg of Valdecoxib orally twice a day
OTHER	Blood samples	Blood samples for aggregometry are taken before induction of anesthesia, 1h after first drug intake, 4hs and 24hs after first intake

Timeline

• Start date: 2004-02-01
• Primary completion: 2004-12-01
• Completion: 2004-12-01
• First posted: 2008-10-01
• Last updated: 2008-10-01

Locations

1 site across 1 country: Germany