NCT00760331

Long Term Follow up of a Cohort of Children With TCF2 Mutation:Evolution of Endocrine and Renal Function

A Long Term Follow up of a Cohort of Children With TCF2 Mutation:Evolution of Endocrine and Renal Function

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: University Hospital, Limoges · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Anomalies of renal development are well know for patients treated for MODY-5 diabetes due to TCF2 mutation.A recent study confirms the existence of pediatric patients having TCF2 mutation but presenting renal anomalies alone.Endocrine and renal evolution of these patients is unknown.The aim of this study is to follow a cohort of patients with TCF2 mutation and initially presenting renal anomalies alone.

Detailed description

Biologic analysis and renal ultrasonography once a year. After puberty or before kidney transplantation * Abdominal and pelvic MRI * Intravenous Glucose Tolerance Test

Conditions

• Hepatocyte Nuclear Factor 1-beta

Timeline

• Start date: 2008-06-01
• Primary completion: 2033-07-01
• Completion: 2033-12-01
• First posted: 2008-09-26
• Last updated: 2018-08-13

Locations

1 site across 1 country: France