NCT00757887

Re-exposure of EHMI-8 Human Volunteers to Live Malaria Sporozoites

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

In the EHMI-8 study (CMO 2006/207) the investigators induced sterile protection against P. falciparum challenge in healthy Dutch volunteers by repeated exposure to infected mosquitoes whilst under chloroquine prophylaxis. The surprisingly efficient induction of protection in this study strongly supports the development of whole parasite vaccines and is therefore an important finding to malaria vaccine development. In this study (EHMI8B) the investigators would like to explore the longevity of the protective immune response and simultaneously further characterise immune mechanisms responsible for protection by re-exposing EHMI-8 volunteers to infected mosquito bites.

Conditions

• P. Falciparum Malaria

Interventions

Type	Name	Description
BIOLOGICAL	Exposure to 5 P. falciparum infected mosquitoes	Five Anopheles Stephensi mosquitoes are infected with NF54 P.falciparum. volunteers are exposed to bites for 10 minutes.

Timeline

• Start date: 2009-10-01
• Primary completion: 2010-08-01
• Completion: 2010-08-01
• First posted: 2008-09-23
• Last updated: 2010-11-09

Locations

1 site across 1 country: Netherlands