NCT00755911

Treatment of Alveolar Bone Defects Using Aastrom Biosciences Autologous Tissue Repair Cell Therapy

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: University of Michigan · Academic / Other
• Sex: All
• Age: 20 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this research is to determine if a subject's own bone marrow tissue can help regenerate bone in the area of his/her jaw where a tooth has been removed using Tissue Repair Cell (TRC) Therapy.

Detailed description

A sample of the subject's bone marrow tissue will be collected and sent to a laboratory where it will be processed to form cells. The new cells are transplanted into the tooth socket after the tooth has been removed. The researchers are testing to see if these cells (TRC) will help form bone. The research will also determine if the implant the subject receives will be more stable in the area with new bone growth.

Conditions

• Alveolar Bone Loss

Interventions

Type	Name	Description
BIOLOGICAL	Tissue Repair Cells (TRC)	30-50 ml of bone marrow is aspirated from subject and processed into TRC autologous bone marrow tissue graft. 10ml of TRC will be absorbed onto gelfoam carrier and placed in extraction socket.
DEVICE	Control	Control subjects only receive standard gelfoam carrier. It promotes healing after tooth extraction

Timeline

• Start date: 2008-06-01
• Primary completion: 2011-12-01
• Completion: 2012-05-01
• First posted: 2008-09-19
• Last updated: 2015-07-03
• Results posted: 2014-04-15

Locations

1 site across 1 country: United States