NCT00751322

Transfusion-Induced Alterations of Pulmonary and Immune Function in Mechanically Ventilated Patients

Project 2 (Mayo): Transfusion-Induced Alterations of Pulmonary and Immune Function in Mechanically Ventilated Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Specific aim: To test whether transfusion of leukoreduced red cells of lesser storage time (versus conventional storage time) reduces mild alterations in pulmonary function and immune activation in critically ill patients with mechanically ventilated lungs. We propose to perform a prospective, randomized, double-blind clinical trial in critically ill patients whose lungs are mechanically ventilated, and who have orders to receive transfusion of at least one unit of packed red cells, comparing pulmonary function between patients randomly allocated to receive a unit of red cells stored for 5 days or less, with similar patients randomly allocated to receive a unit of red cells stored conventionally (median 21 days). We will test the hypothesis that transfusion of red cells of lesser storage age, (5 days or less) will produce the less changes of pulmonary function and immune activation than will transfusion of red cells of conventional storage age (median 21 days).

Detailed description

Specific aim: To test whether transfusion of leukoreduced red cells of lesser storage time (versus conventional storage time) reduces mild alterations in pulmonary function and immune activation in critically ill patients with mechanically ventilated lungs.

Conditions

• Pulmonary Edemas
• Blood Protein Disorders

Interventions

Type	Name	Description
OTHER	RBC transfusion of 5 days or less storage age	RBC transfusion of 5 days or less storage age
OTHER	RBC transfusion of conventional storage age	RBC transfusion of conventional storage age

Timeline

• Start date: 2008-08-01
• Primary completion: 2010-07-01
• Completion: 2011-12-01
• First posted: 2008-09-11
• Last updated: 2012-01-31

Locations

1 site across 1 country: United States