NCT00750451

Low Molecular Weight Heparin in Recurrent Implantation Failure

Empirical Low Molecular Weight Heparin Administration in the Luteal Phase in Patients With Recurrent Implantation Failures: a Randomized Open Labeled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: —
• Sponsor: V.K.V. American Hospital, Istanbul · Academic / Other
• Sex: Female
• Age: 18 Years – 38 Years
• Healthy volunteers: Not accepted

Summary

Recurrent implantation failure is the failure to achieve a pregnancy after multiple attempts with in vitro fertilization treatment. The reason is usually obscure. Many empirical treatments have been offered without substantial evaluation. Heparin is thought to play a role in the embryo implantation process beyond its anticoagulation effects. The proposed study aims to assess the effectiveness and safety of empirical administration of low molecular weight heparin in patients undergoing a new IVF treatment cycle after multiple failed attempts.

Conditions

• Infertility
• Fertilization in Vitro
• Recurrent Implantation Failure

Interventions

Type	Name	Description
DRUG	low molecular weight heparin (enoxaparine sodium)	1 mg/kg/day subcutaneously in the luteal phase after IVF treatment
DRUG	crinone 8% gel	routine luteal phase support with progesterone gel

Timeline

• Start date: 2006-01-01
• Primary completion: 2008-05-01
• Completion: 2008-05-01
• First posted: 2008-09-10
• Last updated: 2009-03-20

Locations

1 site across 1 country: Turkey (Türkiye)