NCT00749619

Addition of Heparin to Taurolock-TM CLS in HD Patients With TCC Dose it Improve Catheter Patency Problems ?

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: —
• Sponsor: Western Galilee Hospital-Nahariya · Other Government
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Addition of Heparin to the Catheter Lock Solution (CLS): Taurolock-TM will improve the vascular patency compared to Taurolock-TM alone , in hemodialysis patients with Tunneled Cuffed Catheter(TCC) as vascular access.

Detailed description

Bacteremia and thrombosis are the major complications of TCC used for hemodialysis.Instilation of CLS containing antibiotic-anticoagulant solution in the end of each dialysis session till the next dialysis ,can prevent Catheter related bacteremia (CRB).In previous study in our department, Taurolock-TM decreased the rate of CRB but increased the incidence of catheter malfunction. The aim of the study is to investigate the influence of of Heparin addition to CLS-Taurolock- TM ( Taurolidine \&citrate 4%) in prevention of catheter patency problems in HD patients with TCC, in addition to CRB prevention. Methods : Patients with newly inserted TCC for HD enrolled and randomized to receive one of three CLS types : group 1- Taurolock-TM, Group 2 - Taurolock-TM and Heparin , Group 3- Heparin .Patients were followed for 6 monthes. The objective of the study is to investigate the effect of Taurolock TM with heparin on the rate of CRB and vascular patency.

Conditions

• End Stage Renal Disease
• Hemodialysis

Interventions

Type	Name	Description
OTHER	Catheter Lock Solution Taurolidine and Citrate
OTHER	Catheter Lock Solution :Taurolidine and Citrate and Heparin
OTHER	Catheter Lock Solution : Heparin

Timeline

• Start date: 2007-05-01
• Primary completion: 2008-08-01
• Completion: 2008-08-01
• First posted: 2008-09-09
• Last updated: 2008-09-09

Locations

1 site across 1 country: Israel