NCT00748228

Dopamine in Orthostatic Tolerance

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

One goal of this study is to determine whether people with different amounts of dopamine-beta-hydroxylase (DBH) have different responses to events that affect blood pressure and heart rate. We will also study whether increasing dietary salt improves symptoms during upright posture. Finally, we will examine whether the dietary sodium level influences serum DBH activity and whether DBH level influences the response to sodium. DBH levels and the function of the sympathetic or involuntary nervous system will be assessed in normal volunteers and in patients with postural tachycardia syndrome (POTS).

Conditions

• Postural Tachycardia Syndrome

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	dietary sodium	10 mEq/day
DIETARY_SUPPLEMENT	dietary sodium	300 mEq/day
DIETARY_SUPPLEMENT	dietary sodium	150 mEq/day dietary sodium

Timeline

• Start date: 2004-11-01
• Primary completion: 2012-07-01
• Completion: 2012-07-01
• First posted: 2008-09-08
• Last updated: 2015-06-15

Locations

1 site across 1 country: United States