NCT00746226

Probiotics for Birch Pollen Allergy

Probiotic Intervention for Children With Birch Pollen Allergy

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 47 (actual)
• Sponsor: Danisco · Industry
• Sex: All
• Age: 2 Years – 10 Years
• Healthy volunteers: Not accepted

Summary

Birch pollen allergy is one of the most common forms of respiratory allergy in the Nordic countries. Treatment consists of antihistamine use. Specific probiotic strains have been observed to modulate the immune system. Since the body has a common mucosal immune system; it was hypothesised that consumption of probiotics may affect also the respiratory mucosal immune response and hence affect respiratory allergy. Earlier studies with probiotics had been unable to show improvements in adults with pollen allergy. It was therefore hypothesised that children, who's immune system is not yet fully developed, might be better targets.

Conditions

• Rhinitis, Allergic, Seasonal

Interventions

Type	Name	Description
BIOLOGICAL	Lactobacillus acidophilus and Bifidobacterium lactis	Daily 5x10\^9 CFU of a combination of L. acidophilus and B. lactis
BIOLOGICAL	Placebo	Microcrystalline cellulose As capsule which could be opened

Timeline

• Start date: 2006-03-01
• Primary completion: 2006-06-01
• Completion: 2007-02-01
• First posted: 2008-09-03
• Last updated: 2008-09-03

Locations

1 site across 1 country: Finland