Trials / Completed
CompletedNCT00746044
Measurement of MRP2 Function Using Urinary Coproporphyrins
Evaluation of the Ratio of Urinary Coproporphyrins I and III as a Potential Biomarker of MRP2 Function in Man
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 40 (actual)
- Sponsor
- University Hospital, Tours · Academic / Other
- Sex
- All
- Age
- 18 Years – 85 Years
- Healthy volunteers
- Accepted
Summary
Human Multidrug Related Protein 2 (MRP2) excretes several drugs and could therefore modulate their elimination. Individual's MRP2 activity is under genetic control. Thus it would be very useful to get an easily measurable biomarker reflecting individual's MRP2 activity. We aimed to investigate the ratio of urinary coproporphyrins I and III (UCP(I/I+III), known to be increased in patients with mutations in MRP2/ABCC2 gene.
Conditions
Timeline
- Start date
- 2008-02-01
- Primary completion
- 2008-04-01
- Completion
- 2009-04-01
- First posted
- 2008-09-03
- Last updated
- 2009-05-15
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT00746044. Inclusion in this directory is not an endorsement.