Trials / Completed
CompletedNCT00745719
Parathyroidectomy in Endstage Renal Disease
A Pilot Study to Evaluate the Efficacy of Total Parathyroidectomy in Retarding Cardiovascular Calcification in End-stage Renal Disease Patients
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 122 (actual)
- Sponsor
- The University of Hong Kong · Academic / Other
- Sex
- All
- Age
- 18 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
To test the hypothesis that total parathyroidectomy retards cardiovascular calcification, improves bone mineral density, reduces cardiac hypertrophy and arterial stiffening in end-stage renal disease patients on maintenance dialysis.
Detailed description
Secondary hyperparathyroidism (SHPT) in patients with end-stage renal disease contributes to increased cardiovascular morbidity and mortality via different mechanisms. Uncontrolled hyperparathyroidism is associated with left ventricular hypertrophy and has been implicated in the development of cardiac interstitial fibrosis and diastolic dysfunction.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | parathyroidectomy | total parathyroidectomy with forearm autografting |
Timeline
- Start date
- 2007-03-01
- Primary completion
- 2011-09-01
- Completion
- 2012-01-01
- First posted
- 2008-09-03
- Last updated
- 2020-08-05
Locations
1 site across 1 country: Hong Kong
Source: ClinicalTrials.gov record NCT00745719. Inclusion in this directory is not an endorsement.