NCT00745446

The Effect of a Retrofit Particle Trap on the Vascular Effects of Diesel Exhaust Inhalation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: University of Edinburgh · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine whether a retrofit particle trap can reduce the adverse vascular responses to diesel exhaust inhalation

Detailed description

18 subjects healthy male volunteers will be recruited at Umeå University. In a randomised, double blind 3 way crossover trial, subjects will be exposed to filtered air, diesel exhaust (300mcg/m3) or filtered diesel exhaust for 1 hour during intermittent exercise. 2 hours following the exposure, thrombogenicity will be assessed using the Badimon chamber - an ex-vivo model of thrombosis formed under constant flow conditions. Forearm blood flow in response to infused intra-brachial vasodilators will be measured using venous occlusion plethysmography 6 hours after the exposure. Arterial stiffness will be measured using peripheral arterial applanation tonometry in the hour post-exposure. Blood samples will be collected at timepoints over the 24 hours after exposure.

Conditions

• Heart Disease

Interventions

Type	Name	Description
PROCEDURE	Forearm Venous Occlusion Plethysmography	Forearm venous occlusion plethysmography with intra-arterial infusion of Acetylcholine (5-20mcg/min), bradykinin (30-300mcg/min), sodium nitroprusside (2-8mcg/min) and Verapamil (2-10 mcg/min) into non-dominant brachial artery

Timeline

• Start date: 2007-09-01
• Primary completion: 2008-02-01
• Completion: 2008-02-01
• First posted: 2008-09-03
• Last updated: 2008-09-05

Locations

1 site across 1 country: Sweden