NCT00743587

A Study To Assess The Ability Of Tramadol, Naproxen And Oxycodone To Affect The Pain Thresholds Of Patients With Osteoarthritis Of The Thumb

A Randomized, Double-Blind, Placebo And Active Controlled Methodology Study Investigating The Effects Of Tramadol And Naproxen On The Pain Thresholds Of Patients With Severe Pain Due To Osteoarthritis Of The Thumb

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Pfizer · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if the measurement of pressure pain thresholds, in patients suffering osteoarthritis of the thumb, can be used to assess the activity of potential analgesic agents after a single dose. The study will use agents known to give pain relief in osteoarthritis as positive controls. These agents are: tramadol, naproxen and oxycodone.

Conditions

• Osteoarthritis Thumbs

Interventions

Type	Name	Description
DRUG	Placebo	Oral, a double-dummy approach will be used to maintain the blind between active tablet and capsule doses
DRUG	Oxycodone	Oral, 1 x 20mg controlled-release tablets
DRUG	Tramadol	Oral, 2 x 50mg immediate release capsules
DRUG	Naproxen	Oral, 1 x 500mg enteric-coated

Timeline

• Start date: 2008-09-01
• Primary completion: 2009-03-01
• Completion: 2009-03-01
• First posted: 2008-08-29
• Last updated: 2018-12-04

Locations

1 site across 1 country: Belgium