NCT00742040

Rapid Versus Prolonged Inpatient Up-Titration of Captopril

Rapid Versus Prolonged Inpatient Up-Titration of Captopril: A Randomized Clinical Trial

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: The Hospital for Sick Children · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The primary objective of this study is to establish a safe and effective method of up-titration of captopril for hospital inpatients.

Detailed description

Angiotensin converting enzyme inhibitors (ACEi) are one of the most frequently prescribed pediatric cardiac medication and overall their safety in children is widely accepted. Pediatric formulary recommendations for ACEi suggest starting with a low initial dose (0.1 mg/kg), to avoid hypotension, and up-titration for a maintenance dose. However, side ranges are quoted for maintenance doses and no guidance is given as to the best method of up-titration, The physician is left uncertain of the optimal dose and how best to achieve it. The ultimate goal of this study is to be in a position to provide physicians caring for children with heart disease information about how to safely up-titrate this widely used medication, and by doing so to improve dosing in the wider pediatric population.

Conditions

• Heart Disease

Interventions

Type	Name	Description
DRUG	Captopril	A rapid 3-day up-titration protocol
DRUG	Captopril	A slower 9-day up-titration protocol

Timeline

• Start date: 2008-08-01
• Primary completion: 2009-08-01
• Completion: 2009-12-01
• First posted: 2008-08-27
• Last updated: 2008-08-27

Locations

1 site across 1 country: Canada