NCT00741728

Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population

Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population. The Paris Prospective Study III

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 10,157 (actual)
• Sponsor: Institut National de la Santé Et de la Recherche Médicale, France · Other Government
• Sex: All
• Age: 50 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The aim of the present Paris Prospective Study III (PPS3) is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2) to evaluate the respective contribution of heart rate, blood pressure variations and carotid properties to cardiovascular morbidity and mortality including sudden death during 10 years at least in healthy considered subjects.

Detailed description

Overall, 10 157 men and women have been recruited during May 2008 and June 2012 for an extensive clinical examination including a 2h holter electrocardiography (ECG), a carotid doppler echo tracking, a step test, as well as blood and DNA collections. Since then, the cardiovascular morbidity and mortality of the participants is being followed up for 10 years at least and will continue up to 2032.

Conditions

• Community Based Study
• Cardiovascular Disease
• Sudden Death
• Blood Pressure

Interventions

Type	Name	Description
OTHER	Spider flash ECG, high-precision carotid echo-tracking, step test	cardiac rhythm recorded during health check up, vascular aging parameters and baroreflex sensitivity recorded during carotid echotracking of the right common carotid artery , step test during 2 minutes

Timeline

• Start date: 2008-05-13
• Primary completion: 2032-06-01
• Completion: 2032-12-01
• First posted: 2008-08-26
• Last updated: 2026-02-11

Locations

1 site across 1 country: France