NCT00741117

Conjugated Hyperbilirubinemia and Pulse Oximetry

The Influence of Conjugated Hyperbilirubinemia on Pulse Oximetric Accuracy in Liver Disease

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 4 (actual)
• Sponsor: Emory University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if higher levels of bilirubin in the blood of people with liver disease affects how accurate a pulse oximeter machine is able to measure the concentration of oxygen in the blood. Previous studies have reported conflicting results regarding the affect of high levels of bilirubin in the blood on the accuracy of the pulse oximeter reading. Initial studies showed an underestimation of the oxygen concentration in the presence of elevated bilirubin. Subsequent studies have suggested that high levels of bilirubin in the blood do not influence the accuracy of the pulse oximeter machine. However, recent reports in bone marrow transplant literature and our personal observations in patients with liver disease suggest that high bilirubin levels are associated with an overestimation of the oxygen concentration as measured by the pulse oximeter machine.

Conditions

• Liver Disease
• Hyperbilirubinemia

Interventions

Type	Name	Description
PROCEDURE	Arterial Blood Gas	One blood gas sample will be obtained from an artery in the arm.
PROCEDURE	Pulse Oximetry Machine	A pulse oximetry machine will be used at one time point to obtain an oxygen saturation reading. This is done by placing a clip onto the finger. The pulse oximetry value displays on the pulse oximeter machine within seconds.
PROCEDURE	Direct and Indirect Serum Bilirubin Measurement	One tube of blood will be drawn from a vein in the arm at one timepoint to measure the direct and indirect serum bilirubin levels.

Timeline

• Start date: 2011-10-01
• Primary completion: 2011-10-01
• Completion: 2011-10-01
• First posted: 2008-08-26
• Last updated: 2013-03-06

Locations

1 site across 1 country: United States