Trials / Unknown

UnknownNCT00739544

Chronic Pain After Operation for Breast Cancer

Examination of Healthy Female Subjects in the Project: Disposing Factors for Chronic Pain After Operation for Breast Cancer

Status: Unknown
Phase: EARLY_Phase 1
Study type: Interventional
Enrollment: 20 (estimated)

Sponsor: Rigshospitalet, Denmark · Academic / Other
Sex: Female
Age: 18 Years – 70 Years
Healthy volunteers: Accepted

Summary

The purpose of this study is to identify intraindividual as well as iatrogenic factors disposing for the development of chronic and acute pains after surgery for breast cancer in order to improve treatment and prevent the development of acute and chronic postoperative pains.

Detailed description

Surgery for breast cancer is followed by acute undesirable sequelae (pain, nausea, vomiting, psycho-social adaptation) and late sequelae with discomfort or more severe neuropathic pain problems in the surgical area due to nerve damage or adjuvant-/radiotherapy. The late sequelae occur in 30-50% of patients but the exact mechanisms (preoperative disposing factors, intraoperative nerve damage/inflammatory response), acute postoperative pain and psychosocial factors remain to be determined in large, detailed, well-described studies, including stratification to modern breast cancer treatment (sentinel node strategy/ radiotherapy/ chemotherapy). The present study will describe in detail preoperative psychosocial/genetic pain mechanisms, intraoperative technique, multi-modal anaesthesia and opioid-reduced analgesia with a detailed, early and late postoperative follow-up with neurophysiological assessment in the surgical area and randomised studies on preventive therapy.

Conditions

Pain Threshold

Interventions

Type	Name	Description
OTHER	1	Testing with thermal sensor testing device, von Frey filaments, cotton wisp, turning fork, pressure gauge device

Timeline

Start date: 2008-08-01
Primary completion: 2010-03-01
Completion: 2010-03-01
First posted: 2008-08-21
Last updated: 2008-08-21

Locations

1 site across 1 country: Denmark

Source: ClinicalTrials.gov record NCT00739544. Inclusion in this directory is not an endorsement.