NCT00738348

Effect of Perioperative Sivelstat Administration for Liver Resection

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Kochi University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

It is reported that sivelstat improved and preserved the postoperative renal function in the orthopedic management. Moreover because sivelstat reduced the migration of neutrophil, it improved acute lung injury. During liver resection, Pringle maneuver, clamping the hepatoduodenal ligament, was performed. Pringle maneuver causes reperfusion injury of the liver. We have a hypothesis that sivelstat prevent the warm shock of reperfusion injury of the liver by Pringle maneuver.

Detailed description

Whether the incidence of postoperative morbidities, such as liver failure, renal failure, or congestive heart failure, was reduced by administration of perioperative sivelstat.

Conditions

• Liver Diseases

Interventions

Type	Name	Description
DRUG	sivelstat	sivelstat sodiumhydrate
DRUG	glucose	glucose

Timeline

• Start date: 2007-04-01
• Primary completion: 2008-05-01
• Completion: 2008-07-01
• First posted: 2008-08-20
• Last updated: 2012-06-08

Locations

1 site across 1 country: Japan