NCT00738192

Comparison of Analgesic Efficacy of Fentanyl, Sufentanil and Butorphanol After Remifentanil Anesthesia

Comparison of Analgesic Efficacy of Fentanyl, Sufentanil and Butorphanol After Remifentanil Anesthesia in Gynecological Laparoscopic Surgeries

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: Nanjing Medical University · Academic / Other
• Sex: Female
• Age: 19 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Fast awakening from anesthesia is one of the major characteristics of remifentanil-associated anesthetic induction and maintenance, whereas corresponding pain during awakening influences patient's rehabilitation strongly. In addition, such early postoperative pain results in significant stress responses, which displays as further release of stress hormones such as cortisol and β-endorphin as well. How to prevent such acute pain resulting from remifentanil's fast metabolism endows clinical significance. This study is designed to compare the analgesic efficacy of fentanyl, sufentanil and butorphanol delivered after gynecological laparoscopic surgeries that underwent remifentanil induction and maintenance, and investigate corresponding influence on the levels of blood cortisol and β-endorphin.

Conditions

• Postoperative Pain

Interventions

Type	Name	Description
DRUG	Fentanyl citrate	Fentanyl 0.5 μg/kg delivered intravenously immediate at the end of remifentanil pump finished
DRUG	Sufentanil citrate	Sufentanil 0.05 μg/kg delivered intravenously immediate at the end of remifentanil pump finished
DRUG	Butorphanol tartrate	Butorphanol 0.01 mg/kg delivered intravenously immediate at the end of remifentanil pump finished

Timeline

• Start date: 2008-07-01
• Primary completion: 2009-03-01
• Completion: 2009-03-01
• First posted: 2008-08-20
• Last updated: 2009-03-11

Locations

1 site across 1 country: China