NCT00737919

The Influence of Dietary Plant Sterols and Plant Stanols on Cholesterol and Plant Sterol Levels in Atheromatous Plaques

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University of Helsinki · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study aims to explore whether the increased supply of dietary plant sterols and plant stanols have any influence on serum levels of phytosterols and on consistency of carotid atheromatous plaques.

Detailed description

This is a double-blind randomized study. The study population will consist of 30 consecutive patients who will undergo an elective carotid endarterectomy due to a tight asymptomatic stenosis. The patients will be randomized into two groups consuming either plant sterol (2g/day) or plant stanol (2g/day) spreads for two to six weeks, until the operation. Serum lipids, lipoproteins and sterols will be analyzed at the randomization, before the operation and one month after the operation. The carotid arteries will be examined for their composition of sterols. This study gives new information concerning the relationship between dietary consumption of plant sterols and stanols and the sterol composition of the carotid plaques.

Conditions

• Atherosclerosis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Plant Stanol	Plant stanols in margarines daily 2 grams
DIETARY_SUPPLEMENT	Plant Sterol	Plant sterols in margarines daily 2 grams

Timeline

• Start date: 2006-05-01
• Primary completion: 2009-12-01
• Completion: 2009-12-01
• First posted: 2008-08-20
• Last updated: 2011-02-10

Locations

1 site across 1 country: Finland