Trials / Completed
CompletedNCT00734929
Aprepitant With Dexamethasone Versus Ondansetron With Dexamethasone for PONV Prophylaxis in Patients Having Craniotomy
A Comparison of the Combination of Aprepitant and Dexamethasone Versus the Combination of Ondansetron and Dexamethasone for the Prevention of Postoperative Nausea and Vomiting (PONV) in Patients Undergoing Craniotomy
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 115 (actual)
- Sponsor
- Duke University · Academic / Other
- Sex
- All
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
We hypothesize that the combination of aprepitant with dexamethasone will provide significantly improved prophylaxis against Postoperative nausea and vomiting compared with the combination of ondansetron and dexamethasone, in patients undergoing craniotomy under general anesthesia.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Aprepitant + Dexamethasone | Aprepitant 40 mg + Dexamethasone 10 mg |
| DRUG | Ondansetron + Dexamethasone | Ondansetron 4 mg + Dexamethasone 10 mg |
Timeline
- Start date
- 2007-09-01
- Primary completion
- 2009-06-01
- Completion
- 2009-06-01
- First posted
- 2008-08-14
- Last updated
- 2017-03-13
- Results posted
- 2011-06-03
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00734929. Inclusion in this directory is not an endorsement.