NCT00730418

Effects of Chronic Use of Doxazosin in Men With Benign Prostatic Hyperplasia

A Prospective Study for the Effects of Chronic Use of Doxazosin on Alpha 1-adrenergic Receptors in Men With Benign Prostatic Hyperplasia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: Samsung Medical Center · Academic / Other
• Sex: Male
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

In this study, we investigate the changes of the expression of alpha adrenergic receptor in the prostate tissue during 2-yr medication period in the man with benign prostatic hyperplasia. And we also evaluate the efficacy and safety of 24 mo-treatment with doxazosin (4mg, 8mg)

Detailed description

To compare the expression of alpha-1 adrenergic receptors, we will use various methodologies such as * Real-time RT-PCR * Radioligand receptor binding * Western blot * Immunohistochemistry

Conditions

• Benign Prostatic Hyperplasia

Interventions

Type	Name	Description
DRUG	Doxazosin	Treatment with doxazosin 4mg daily for 24 mos
DRUG	Doxazosin	Treatment with doxazosin 8mg daily for 24 mos

Timeline

• Start date: 2007-01-01
• Primary completion: 2010-03-01
• Completion: 2010-03-01
• First posted: 2008-08-08
• Last updated: 2010-08-26

Locations

1 site across 1 country: South Korea