Trials / Terminated
TerminatedNCT00725946
Pilot Study to Determine Radioiodide Accumulation and Dosimetry in Breast Cancers Using 124I PET/CT
A Pilot Study to Determine Radioiodide Accumulation and Dosimetry in Breast Cancers Using 124I PET/CT
- Status
- Terminated
- Phase
- EARLY_Phase 1
- Study type
- Interventional
- Enrollment
- 7 (actual)
- Sponsor
- Stanford University · Academic / Other
- Sex
- Female
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This is a pilot imaging study for women whose tumors express NIS \[Na+I- symporter, sodium iodide symporter\]. Eligibility is limited to the presence of strong (3+) and/or plasma membrane staining in \> 20% of cells as determined by immunohistochemical methods. A total of 10 patients will be imaged with 124I PET/CT (serial scans over 24 hour period) to determine radioiodide uptake and distribution in tumor tissue. Thyroid iodide uptake and retention will be blocked beginning one week prior to 124I PET/CT scan with thyroid hormone (T3) and methimazole (impedes organification). Tumor, organ and whole body dosimetry will be calculated in each patient.
Conditions
- Breast Cancer
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Breast Cancer Metastatic Breast Cancer
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Iodine-124 | |
| RADIATION | PET/CT with Iodine-124 |
Timeline
- Start date
- 2008-02-01
- Primary completion
- 2012-12-01
- Completion
- 2012-12-01
- First posted
- 2008-07-31
- Last updated
- 2017-10-11
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00725946. Inclusion in this directory is not an endorsement.