NCT00723320

Effect of Atorvastatin and Lifestyle Intervention on Progression of Pre-Clinical Atherosclerosis

Effect of Atorvastatin and Lifestyle Intervention on Progression of Carotid Intima-Media Thickness in Chinese People Without Manifest Atherosclerotic Disease

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,200 (estimated)
• Sponsor: Ministry of Science and Technology of the People´s Republic of China · Other Government
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether atorvastatin, aggressive lifestyle intervention, and their interaction are effective in delaying the progress of pre-clinical atherosclerosis.

Detailed description

Primary prevention of atherosclerotic disease remains a big challenge. Currently, it is not clear how to treat those subjects with evidence of pre-clinical atherosclerosis but without obvious conventional risk factors. This randomized, placebo controlled, double blind study is to evaluate the effect of Atorvastatin 10 mg daily, therapeutic lifestyle change, and their combination, on the progression of CIMT in those with higher baseline CIMT value but are not belong to 'high risk' category, according to the conventional risk factors.

Conditions

• Atherosclerosis

Interventions

Type	Name	Description
DRUG	Atorvastatin	atorvastatin 10mg/d
BEHAVIORAL	Aggressive lifestyle intervention	aggressive lifestyle intervention

Timeline

• Start date: 2008-02-01
• Primary completion: 2010-12-01
• Completion: 2010-12-01
• First posted: 2008-07-28
• Last updated: 2008-08-25

Locations

1 site across 1 country: China