NCT00720772

Intravenous Sodium Thiosulfate on Coronary Calcification in Patients on Hemodialysis

The Treatment Effect of Intravenous Sodium Thiosulfate on Coronary Calcification in Patients on Hemodialysis

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Ramathibodi Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The present study will examine the treatment effect of sodium thiosulfate on coronary calcification in patients on hemodialysis.

Detailed description

Coronary calcification (CAC) is prevalent among patients with end-stage renal disease (ESRD). High serum phosphate, the intake of calcium containing phosphate binder as well as dialysis vintage have been shown to be associated with the increasing prevalence of CAC. High CAC score examined by electron-beam CT scan or multi-slice CT scan associates with an increased cardiovascular mortality in ESRD. In series of case reports, intravenous sodium thiosulfate (STS) reduced the calcium burden in calcific uremic arteriopathy and soft tissue calcification. This was believed to be due to the calcium chelation effect of STS.

Conditions

• Coronary Calcification
• Vascular Calcification

Interventions

Type	Name	Description
DRUG	25% intravenous (IV) sodium thiosulfate	50 ml IV drip twice/week post hemodialysis

Timeline

• Start date: 2008-07-01
• Primary completion: 2009-05-01
• Completion: 2009-11-01
• First posted: 2008-07-23
• Last updated: 2009-12-17

Locations

1 site across 1 country: Thailand