NCT00719056

Teicoplanin Prophylaxis for Total Hip or Knee Arthroplasty

Efficacy of Teicoplanin for the Prevention of Surgical Site Infections After Total Hip or Knee Arthroplasty: A Prospective, Open-Label Randomized Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 616 (actual)
• Sponsor: University of Athens · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a prospective, open-label, randomized clinical trial where patients were administered prophylaxis for total hip or knee arthroplasty either with teicoplanin or with other antibiotics. The study is aiming to evaluate any differences between these two different strategies of antimicrobial prophylaxis in the occurrence of surgical site infections

Detailed description

This is a prospective, open-label, randomized clinical trial where patients were administered prophylaxis for total hip or knee arthroplasty either with a single dose of teicoplanin or with multiple doses of other antibiotics according to the habits of the attending physicians aiming to evaluate any differences between these two different strategies of antimicrobial prophylaxis in the occurrence of surgical site infections

Conditions

• Total Hip and Knee Arthroplasties

Interventions

Type	Name	Description
DRUG	Teicoplanin	The selected dose was 10mg/kg and it was given intravenously by a catheter inserted under aseptic conditions in a forearm vein within 15 minutes; it was diluted in one 5% glucose solution of a 50 ml final volume
DRUG	β-lactams or ciprofloxacin	Multiple doses for up to six consecutive days

Timeline

• Start date: 2004-08-01
• Primary completion: 2005-12-01
• Completion: 2007-12-01
• First posted: 2008-07-21
• Last updated: 2008-07-21

Locations

3 sites across 1 country: Greece