Trials / Terminated
TerminatedNCT00718185
Pharmacokinetics and Pharmacdynamics of Sildenafil
The Pharmacokinetics and Pharmacodynamics of Sildenafil in Pediatric and Adult Patients
- Status
- Terminated
- Phase
- —
- Study type
- Observational
- Enrollment
- 9 (actual)
- Sponsor
- Children's Hospital of Philadelphia · Academic / Other
- Sex
- All
- Age
- 28 Days
- Healthy volunteers
- Not accepted
Summary
The study is being done to investigate what happens to sildenafil in the body and how long it takes to get rid of this drug. Understanding how long the drug stays in the body and how it is changed by the body will help doctors determine the best dose. We also want to learn how well the medicine works based on the size of the dose or amount in the bloodstream.
Detailed description
There is no data regarding sildenafil drug disposition in infants and children with pulmonary hypertension. Sildenafil is used at The Children's Hospital of Philadelphia for the treatment of pulmonary hypertension. Patients receiving sildenafil as standard of care will be approached for consent.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Obtain blood specimens | Obtain blood samples at multiple timepoints. |
Timeline
- Start date
- 2008-05-01
- Primary completion
- 2009-12-01
- Completion
- 2010-02-01
- First posted
- 2008-07-18
- Last updated
- 2015-03-12
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00718185. Inclusion in this directory is not an endorsement.