NCT00717574

Addition of Nitrous Oxide and Its Effects on Depth of Anesthesia

Addition of Nitrous Oxide to a Sevoflurane or Propofol Based Anesthetic and Its Effects on Depth of Anesthesia Indices (N20)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: University of Oklahoma · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

The study hypothesizes that adding 60% nitrous oxide to a steady state sevoflurance or propofol anesthetic will lead to a decrease in both BIS and Entropy indices during a constant level of surgical stimulus

Detailed description

Nitrous oxide is a widely used general anesthetic pas. It is often used in addition to a second, more potent agent. BIS and Entropy are depth of anesthesia monitors in clinical use. There are conflicting reports about the usefulness of these monitors when nitrous oxide is used as a part of the anesthetic regimen. While some studies demonstrate a decrease in BIS and Entropy, this study aims to investigate the effects of adding nitrous oxide to a sevoflurane or a propofol based anesthetic on BIS and Entropy indices.

Conditions

• Deep Sedation
• Anesthesia, General

Interventions

Type	Name	Description
DRUG	Sevoflurane group	Addition of 60% nitrous oxide for 20 minutes duration, then back to 1:1 oxygen/air mixture.
DRUG	Propofol group	Addition of 60% nitrous oxide for 20 minutes duration, then back to 1:1 oxygen/air mixture.

Timeline

• Start date: 2008-03-01
• Primary completion: 2010-10-01
• Completion: 2010-10-01
• First posted: 2008-07-17
• Last updated: 2017-07-31
• Results posted: 2017-06-28

Locations

1 site across 1 country: United States