NCT00716950

Valsartan and Amlodipine Compared to Losartan and Amlodipine in Hypertensive Patients

Evaluation of Antihypertensive Activity of Valsartan and Amlodipine Compared to Losartan and Amlodipine Through Ambulatory Blood Pressure Monitoring in Moderate Hypertensive Patients in a Randomized, Controlled, Double-Blind Study

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 187 (estimated)
• Sponsor: University of Pavia · Academic / Other
• Sex: All
• Age: 35 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Hypertensive patients with moderate hypertension have a risk to develop cardiovascular events of 15-20% over a period of 10 years. It is important to reach quickly the advised target, but often this result can be obtained with a combination therapy. Some evidences demonstrate sartans and calcium channels blockers can be very useful and safe, but it is also important to verify which association can give side effects or give some pharmacokinetic interactions that can negatively influence the clinical combination efficacy.

Conditions

• Essential Hypertension

Interventions

Type	Name	Description
DRUG	valsartan/amlodpine	tablets; 160mg/5mg; od; 4 weeks
DRUG	losartan/amlodpine	tablets; 100mg/5mg; od; 4 weeks

Timeline

• Start date: 2008-07-01
• Primary completion: 2009-02-01
• Completion: 2009-02-01
• First posted: 2008-07-16
• Last updated: 2008-07-17

Locations

1 site across 1 country: Italy