NCT00716690

Multi Donor Mismatched Stem Cell Transplantation (MDT)

Enhancement of Hematopoietic Stem Cell Engraftment by Multi Donor Stem Cell Transplantation (MDT) From 2 Mismatched Donors, a Phase I-II Open Study

• Status: Unknown
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: Hadassah Medical Organization · Academic / Other
• Sex: All
• Age: 70 Years
• Healthy volunteers: Not accepted

Summary

The proposed research focuses on the development of innovative protocol of mismatched stem cell transplantation with combined 2 different haplo stem cell transplantation (SCT) donors which are mismatched to the recipient (and preferably to each other), in a patient in need for SCT, lacking an HLA match related or an unrelated donor. This innovative protocol named multi donor stem cell transplantation (MDT) is designed to facilitate engraftment even when reduced intensity conditioning or a low cell dose are used, improve the graft vs. leukemia (GVL) effect and enhance immune reconstitution (using quantitative and qualitative parameters).

Conditions

• Graft-Versus-Host Disease

Interventions

Type	Name	Description
PROCEDURE	Multi donor stem cell transplantation	stem cell transplantation from 2 donors

Timeline

• Start date: 2008-07-01
• Primary completion: 2020-01-01
• Completion: 2020-06-01
• First posted: 2008-07-16
• Last updated: 2016-02-19

Locations

1 site across 1 country: Israel