NCT00715312

Effect of Oleic Acid on Inflammation Markers and Blood Lipid Metabolites: A Randomised, Double-Blind, Crossover Study

Effect of Oleic Acid on Inflammation Markers and Blood Lipid Metabolites: A Randomised, Double-Blind, Crossover Study.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 43 (actual)
• Sponsor: Malaysia Palm Oil Board · Other Government
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Rationale: The effect of positional distribution of dietary fatty acids on markers of inflammation and blood lipids metabolites on diets containing fatty acids such as oleic acid that are associated with reduced risk of cardiovascular disease is not widely studied. Hypothesis: There would be difference detected in the concentrations of markers of inflammation and blood lipid metabolites in human volunteers fed controlled diets. Study design: A randomized, double-blind, crossover clinical trial that involves 41 healthy volunteers. The volunteers will be selected based on inclusion and exclusion criteria. They will consume controlled diets for 5 weeks that provides 15% of energy from protein, 30% of energy from fat, and 55% of energy from carbohydrates. Volunteers will be assigned to each test diets which is cooked with novel olein, palm stearin or partially hydrogenated soybean oil in random order until all three diets has consumed by each person. Main study parameters: LDL-cholesterol

Conditions

• Inflammation

Interventions

Type	Name	Description
OTHER	Novel Olein	A total of 70g of test oil is incorporated into cooked meal which accounts for 30-35% of calorie intake
OTHER	Novel Olein	A total of 70g of test oil is incorporated into cooked meal which provides 30-35% of calorie

Timeline

• Start date: 2008-02-01
• Primary completion: 2008-06-01
• Completion: 2008-06-01
• First posted: 2008-07-15
• Last updated: 2008-07-15

Locations

1 site across 1 country: Malaysia