NCT00713947

Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Versus Control

Comparative Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Versus Control on the Gastric Lesions Induced by the Aspirin With the Low Dose Among Patients Treated With the Long Course

• Status: Withdrawn
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Low dose of aspirin is the main cause of gastro-duodenal ulcer. The best prevention is not definite particularly in patients without history of ulcer and infected by H. pylori.The aim of the study is to evaluate the gastric damage induced by aspirin in patients with H. pylori infection but who have any history of ulcer.

Detailed description

The aim of the study is to compare the protective effect of H. pylori eradication versus Pantoprazole versus placebo on the gastric damage induced by low dose of aspirin. Treatment are attributed by randomisation. Patients are followed for 6 months and gastric damage are evaluated by endoscopy at the end of this period.

Conditions

• Positive Helicobacter Pylori Serology
• Coronary Thrombosis
• Supra-aortic Artery Thrombosis

Interventions

Type	Name	Description
DRUG	during one week for the active treatments	during one week for the active treatments placebo during 25 weeks
DRUG	Pantoprazole	6 months at 20 mg
DRUG	Placebo Formula 515	26 weeks, one tablet per day

Timeline

• Start date: 2008-04-01
• Primary completion: 2009-03-01
• Completion: 2010-03-01
• First posted: 2008-07-14
• Last updated: 2026-03-12

Locations

1 site across 1 country: France