NCT00713596

Study Evaluating Benefit of Using Fibrin Glue in Septorhinoplasty

The Use of Fibrin Sealant During Septorhinoplasty: Short and Long Term Benefits

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether the use of fibrin glue during nasal surgery leads to a shorter recovery period with less bruising and/or swelling.

Detailed description

Septorhinoplasty is a well established technique to correct nasal deformity. Drawbacks of this procedure include a significant recovery following surgery which may often require nasal taping and casting. Swelling and bruising in and around the surgical site may persist for months after the operation. At present, there is no standard regarding the length of time nasal tape and cast should be used following septorhinoplasty. It has never been proven that taping or casting is required - in surgeries that require minimal amounts of tissue handling, we may not use any tape or cast following the procedure. Homologous fibrin glue has been used for various cosmetic facial plastic procedures since the early 1980's. It has been shown to decrease bruising and swelling following surgery. This study is being undertaken to evaluate these benefits of using fibrin glue in nasal surgery.

Conditions

• Recovery Time
• Bruising

Interventions

Type	Name	Description
DRUG	Fibrinogen	One time application of 0.5 cc to 2.0 cc of fibrinogen following surgery.
PROCEDURE	Septorhinoplasty	Septorhinoplasty to correct nasal deviation.
PROCEDURE	Taping after septorhinoplasty.	Simple taping over the nose following nasal surgery.
PROCEDURE	Cast applied to the nose after nasal surgery	A molded cast will be placed on top of the nose following nasal surgery.
OTHER	Saline	Approximately 0.5 cc to 2 cc normal saline will be applied after the operation before the nasal taping and casting.

Timeline

• Start date: 2008-07-01
• Primary completion: 2010-01-01
• Completion: 2010-01-01
• First posted: 2008-07-11
• Last updated: 2016-04-18
• Results posted: 2012-07-24

Locations

1 site across 1 country: United States