NCT00713180

Determinants of Pterygium Occurrence and Recurrence in a Rural African Population

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 355 (estimated)
• Sponsor: Anguria, Peter, M.D. · Individual
• Sex: All
• Age: 21 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to find out why pterygium occurs and recurs in a rural African population. Participants will be interviewed on personal and lifestyle information, family history of pterygium, environmental exposure and history of previous eye inflammation. They will undergo eye examination and photography. Those with pterygium will be operated on to remove pterygium and followed up to detect any recurrence and complications of surgery. The excised pterygium will be examined pathologically and genetically; participant's blood will also be examined genetically. Data will be analyzed for statistically significant differences in findings between pterygium and pterygium free participants. The study hypothesis is that multiple factors are responsible for the occurrence and recurrence of pterygium in a rural african population.

Conditions

• Pterygium

Interventions

Type	Name	Description
PROCEDURE	Pterygium excision followed by grafting	Pterygium will be excised followed by either free conjunctival or limbal conjunctival graft obtained from the upper part of the globe. The graft will be kept in place by sutures

Timeline

• Start date: 2008-08-01
• Primary completion: 2012-02-01
• Completion: 2012-02-01
• First posted: 2008-07-11
• Last updated: 2015-06-25

Locations

1 site across 1 country: South Africa